Relationship between TPO-Ab with aggressive behavior in major mental disorders

Purpose We aimed to explore the relationship between thyroid peroxidase antibody (TPO-Ab) and suicidal aggressive behaviors in patients with major mental disorders. Methods enrolled 812 inpatients disorders (schizophrenia, bipolar disorder, depressive disorder) this retrospective study. Baseline interviews were conducted by two psychiatrists. The patients’ recorded electronic medical record system these evaluated terms of violence suicide according risk assessment form formulated Work Code for Management Treatment Severe Mental Illness Ministry Health China. calculated incidence rates positive TPO-Ab, behaviors. Furthermore, we explored relationships among factors using logistics regression analysis. Results Among patients, 42.6% (n = 346) had TPO-Abs defined as group. Rates aggression 12.7% 103) 10.2% 83) respectively. percentage (13%, n 45) was higher than that negative group (8.2%, 38). In contrast, (9.5%) lower (15.0%) TPO-Ab found increase behavior (odd ratio (OR) 1.64, 95%CI (1.04, 2.59), P 0.03) effect still evident after adjusted function (OR 1.65, (1.03, 2.64), 0.04). subclinical hypothyroidism 2.64, (1.19, 5.85), 0.02) hyperthyroidism 7.03, (2.23, 22.20), 0.001) be but not Conclusion can affect do behaviors, Thus, testing is necessary psychiatric behavior. test helped staff determine advance.